Location: 1180 Postle Hall, 305 W. 12th Ave., Columbus, OH 43210
Presented by: Steven D. Goodman, PhD
Professor of Pediatrics, Director of the Oral GI Microbiology Research Affinity Group, Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital
The Ohio State University College of Medicine
“How the biofilm state puts bacteria to Zzzzzzz”
Summary: Bacterial pathogens in the biofilm state are the etiologic agents of chronic and recurrent infections. Herein, bacteria adopt a community architecture and protect themselves against hazardous conditions (like the host immune response and antimicrobials) by creating an extracellular matrix. This matrix is made up of multiple types of biomolecules but universally contains DNA. Indeed, enzymes that degrade DNA disrupt biofilms but only early in their development; mature biofilms are completely resistant to these same enzymes. The reason for this resistance is due to a novel structure adopted by the extracellular DNA. Targeting this novel DNA structure provides a novel means to disrupt bacterial biofilms across genera and cure chronic and recurrent infections.
Continuing Dental Education credit available. Light refreshments provided.
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