Location: 1180 Postle Hall
“Tasting” Sugars Beyond the Tongue
Presented by: George Kyriazis, PhD
Assistant Professor, Department of Biological Chemistry and Pharmacology, Diabetes and Metabolism Research Center (DMRC)
The Ohio State University College of Medicine
Talk synopsis: Sweet taste receptors (STRs) are nutrient sensing G protein-coupled receptors (GPCRs) that are expressed, beyond the tongue, in tissues such as the gut, pancreas and skeletal muscle. Using genetic mouse models and pharmacological approaches in vivo and ex vivo, we have identified a role of STRs in the regulation of endocrine secretion and nutrient metabolism. In addition, ongoing clinical studies, have revealed an unexpected association between a functional human variant in STRs with glucose tolerance, and other indices of glucose metabolism and regulation.
Continuing Dental Education credit available. Light refreshments provided.
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