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Brian L. Foster, PhD

Academic Title

Assistant Professor

Academic Division

Biosciences

Education

MS/Specialty
​Central Michigan University, 2000, Microbiology

PhD
​University of Washington, 2011, Oral Biology

Contact

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Email: 
foster.1004@osu.edu
Phone: 
614-247-5760
Office Address: 
4163 Postle Hall
305 W. 12th Avenue
Columbus, OH 43210
Lab Address: 
4010 Postle Hall
305 W. 12th Avenue
Columbus, OH 43210

Professional Profile Links

ResearchGate

Research Interests

I study the molecular biology of tooth root development and mineralization, with interests including genes, mechanisms, diseases, and novel regeneration strategies.

Research Support

NIH/NIAMS K99/R00 grant AR 066110

Publications

Ao M, Chavez MB, Chu EY, Hemstreet KC, Yin Y, Yadav MC, Millán JL, Fisher LW, Goldberg HA, Somerman MJ, Foster BL.  Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.  Bone 105:134-147, 2017.  PMID: 28866368. PMCID: PMC5730356.

Soenjaya Y, Foster BL, Nociti, Jr. FH, Ao M, Aubin JE, Holdsworth DW, Hunter GK, Somerman MJ,  Goldberg HA.  Mechanical forces exacerbate periodontal defects in Bsp null mice.  J Dent Res, In press, 2015.

Foster BL, Ao M, Willoughby C, Soenjaya Y, Holm E, Lukashova L, Tran AB, Wimer HF, Zerfas PM, Nociti, Jr. FH, Kantovitz KR, Quan B, Sone ED, Goldberg HA, Somerman MJ.  Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein.  Bone. In press, May, 2015.

Foster BL, Sheen CR*, Hatch NE, Liu J, Cory E, Narisawa S, Kiffer-Moreira T, Sah RL, Somerman MJ,  Millán JL.  Periodontal defects in the A116T knock-in mouse model of odontohypophosphatasia.  J Dent Res 94(5):706-14, 2015.

Wang L, Kantovitz KR, Cullinane A, Nociti FH, Foster BL, Roney J, Tran AB, Introne WJ, Somerman MJ. Skin fibroblasts of individuals with Chediak-Higashi Syndrome (CHS) exhibit hyposensitive immunogenic response.  Orphanet J Rare Dis, 21(9):212, 2014 (Epub ahead of print).

Gasque K, Foster BL, Kuss P*, Yadav MC, Liu J, Kiffer-Moreira T, Hatch NE,  Somerman MJ, Millán JL.  Improvement of the skeletal and dental phenotype in Alpl-/- mice by administration of non-targeted chimeric alkaline phosphatase.  Bone, 72:137-147, 2015.

Zweifler LE, Patel MK, Nociti FH, Wimer HF, Millán JL, Somerman MJ, Foster BL.  Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis. Int J Oral Sci, Dec 12, 2014 (Epub ahead of print).

Wang L, Foster BL, Kram V, Nociti FH, Zerfas PM, Tran AB, Young MF, Somerman MJ. Fibromodulin and biglycan modulate periodontium through TGFβ/BMP signaling. J Dent Res 93(8):780-787, 2014.

Foster BL, Ramnitz MS, Gafni RI, Burke AB, Boyce AM, Lee JS, Wright JT, Akintoye SO, Somerman MJ, Collins MT.  Rare bone diseases and their dental, oral, and craniofacial manifestations.  J Dent Res, 93(7 suppl):7S-19S, 2014.

Nociti FH, Jr., Foster BL, Tran AB, Dunn D, Presland RB, Wang L, Bhattacharyya N, Collins MT, Somerman MJ. Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes.  J Dent Res, 93(2):148-54, 2014.

Foster BL, Nociti FH, Jr. Somerman M.  The rachitic tooth.  Endocr Rev, 35(1):1-34, 2014.

Salmon CR, Tomazela DM, Ruiz KGS, Foster BL, Leme AFP, Sallum EA, Somerman MJ, Nociti FH, Jr.  Proteomic analysis of human dental cementum and alveolar bone. J Proteomics 91:544-555, 2013.

Martins L, Rodrigues TL, Ribeiro MM, Saito MT, Giorgetti AP, Casati MZ, Sallum EA, Foster BL, Somerman MJ, Nociti FH, Jr.  Novel ALPL genetic alteration associated with an odontohypophosphatasia phenotype.  Bone, 56(2):390-397, 2013.

McKee MD, Yadav MC, Foster BL, Somerman MJ, Farqharson C, Millán JL.  Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.  J Dent Res 92(8):721-727, 2013.

Foster BL, Soenjaya Y, Nociti, Jr. FH, Holm E, Zerfas PM, Wimer H, Holdsworth DW, Aubin J, Hunter GK, Goldberg HA, Somerman MJ.  Deficiency in acellular cementum and periodontal attachment in Bsp null mice.  J Dent Res 92(2): 166-172, 2013.

Lau WL, Linnes M, Chu EY, Foster BL, Bartley BA, Somerman MJ, Giachelli CM.  High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease.  Nephrol Dial Transplant 28(1):62-69, 2013.

Foster BL, Nagatomo KJ, Tso HW, Tran AB, Nociti, FH, Jr., Narisawa S, McKee MD, Millán JL, and , Somerman MJ. Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.  J Bone Mineral Res 28(2):271-282, 2013.

Foster BL.  Methods for studying tooth root cementum by light microscopy.  Int J Oral Sci 4(3):119-28, 2012.

Rodrigues TL, Foster BL, Silverio KG, Martins L, Casati MZ, Sallum EA, Somerman MJ, Nociti FH, Jr.  Hypophosphatasia-associated deficiencies in mineralization and gene expression in cultured dental pulp cells obtained from human teeth.  J Endod 38(7):907-912, 2012.

Foster BL, Nagatomo KJ, Nociti FH, Jr., Fong H, Dunn D, Tran AB, Wang W, Narisawa S, Millan JL, and Somerman MJ.  Central role of pyrophosphate in acellular cementum formation.  PLoS ONE, 7(6):e38393, 2012.

Rodrigues TL, Foster BL, Silverio KG, Martins L, Casati MZ, Sallum EA, Somerman MJ, Nociti FH, Jr.  Correction of hypophosphatasia (HPP) associated mineralization deficiencies in vitro by phosphate/pyrophosphate modulation in periodontal ligament cells. J Periodontol, 83(5): 653-63, 2012.

Yadav M, de Oliverira RC, Foster BL, Fong H, Cory E, Narisawa S, Sah RL, Somerman M, Whyte M, Millán JL.  Enzyme replacement prevents enamel defects in hypophosphatasia mice. J Bone Mineral Res, 27(8):1722-34, 2012.

Silverio K, Davidson K, James R, Adams A, Foster BL, Nociti F, Somerman MJ, and Moon R.  The Wnt/β-catenin pathway regulates Bmp2-mediated differentiation of dental follicle cells along a cementoblast / osteoblast pathway.  J Periodontal Res, 47(3): 309-19, 2012.

Rodrigues TL, Nagatomo KJ, Foster BL, Nociti FH, Jr., and Somerman MJ. Modulation of phosphate/pyrophosphate metabolism to regenerate the periodontium. A novel in vivo approach. J Periodontol, 82(12): 1757-66, 2011.

Tada H, Nemoto E, Foster BL, Somerman MJ, and Shimauchi H. Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells.  Bone, 48(6):1409-16, 2011.

Foster BL, Nagatomo KJ, Tompkins KA, Fong H, Dunn D, Chu EY, Guenther C, Kingsley DM, Rutherford RB, and Somerman MJ.  The progressive ankylosis protein (ANK) regulates cementum apposition and extracellular matrix composition. Cells Tissues Organs, 194(5):382-405, 2011.

Hakki SS, Foster BL, Nagatomo KJ, Bozkurt SB, Hakki EE, Somerman MJ,  Nohutcu RM.  Bone Morphogenetic Protein-7 enhances cementoblast function, in vitro. J Periodontol 81(11): 1663-74, 2010.

Chu EY, Fong H, Blethen FA, Tompkins KA, Foster BL, Yeh KD, Nagatomo KJ, D. Matsa-Dunn D, Sitara D, Lanske B, Rutherford RB, and Somerman MJ.  Ablation of systemic phosphate regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex. Anat Rec 293(7): 1214-26, 2010.