John D. Bartlett, PhD

John Bartlett
Academic Title
Associate Dean for Research

University of New Hampshire, 1984, microbiology

University of Vermont, 1990, cell and molecular biology

Academic Division
Office Address

4139 B Postle Hall
305 W. 12th Avenue
43210 OH
United States

Lab Address

3132 Postle Hall
305 W. 12th Avenue
43210 OH
United States

Research Interests

Dr. Bartlett’s research has focused on understanding dental enamel development and the gene expression program that is required to form teeth. He has a particular interest in a gene called “matrix metalloproteinase-20” (MMP20), and he also is investigating the molecular events that cause dental fluorosis and the cellular interactions that are required for healthy enamel formation.


View Dr. Bartlett's publications on NCBI.

Simmer JP, C-C Hu J, Hu Y, Zhang S, Liang T, Wang SK, Kim JW, Yamakoshi Y, Chun YH, Bartlett JD, Smith CE (2021). A Genetic Model for the Secretory Stage of Dental Enamel Formation. J Struct Biol. 2021 Oct 26:107805. doi: 10.1016/j.jsb.2021.107805. Online ahead of print. PMID: 34715329

Shahid S, Bartlett JD. Biology of Extracellular Matrix 10. Karamanos NK. Series Ed. Extracellular Matrix Biomineralization of Dental Tissue Structures (2021). Goldberg, M. and Den Besten. P. Eds. Springer Nature, Cham, Switzerland. 261-270. ISBN 978-3-030-76282-7

Bartlett JD, Smith CE, Hu Y, Ikeda A, Strauss M, Liang T, Hsu Y-H, Trout AH, McComb DW, Freeman RC, Simmer JP, Hu C-C. (2021) MMP20-generated Amelogenin Cleavage Products Prevent Formation of Fan-shaped Enamel Malformations. Sci Rep. May 19;11(1):10570. PMCID: PMC8134442  

Fujiwara N, Whitford GM, Bartlett JD, Suzuki M. (2021) Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells. Environ Pollut.273:116495. PMCID: PMC8272738.

Simmer JP, Hardy NC, Chinoy AF, Bartlett JD, Hu JC How Fluoride Protects Dental Enamel from Demineralization. J Int Soc Prev Community Dent. 2020 Apr 2;10(2):134-141. doi: 10.4103/jispcd.JISPCD_406_19. eCollection 2020 Mar-Apr. Review. PMID: 32670900

Wang SK, Zhang H, Chavez MB, Hu Y, Seymen F, Koruyucu M, Kasimoglu Y, Colvin CD, Kolli TN, Tan MH, Wang YL, Lu PY, Kim JW, Foster BL, Bartlett JD, Simmer JP, Hu JC. (2020) Dental malformations associated with biallelic MMP20 mutations. Mol Genet Genomic Med. Jun 3:e1307. doi: 10.1002/mgg3.1307. PMID: 32495503

Deng H, Fujiwara N, Cui H, Whitford GM, Bartlett JD and Suzuki M. (2020) Histone acetyltransferase promotes fluoride toxicity in LS8 cells. Chemosphere 247: 125825., PMID 31927229

Sukseree S, Schwarze UY, Gruber R, Gruber F, Quiles Del Rey M, Mancias JD, Bartlett JD, Tschachler E and Eckhart L. (2020) ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. Autophagy. 3:1-7. PMID: 31880208

Ikeda A, Shahid S, Blumberg BR, Suzuki M and Bartlett JD. (2019) ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development. Sci Rep. 9:14086. PMID: 31575895.

Deng H, Ikeda A, Cui H, Bartlett JD and Suzuki M. (2019) MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts. Cells. 8, 436:1-14. PMID: 31083332.

Suzuki M, Bartlett JD (2019) Rodent Dental Fluorosis Model: Extraction of Enamel Organ from Rat Incisors. Methods Mol Biol.1922:335-340. PMID: 30838588.

Kim JW, Zhang H, Seymen F, Koruyucu M, Hu Y, Kang J, Kim YJ, Ikeda A, Kasimoglu Y, Bayram M, Zhang C, Kawasaki K, Bartlett JD, Saunders TL, Simmer JP, Hu JC. (2018) Mutations in RELT Cause Autosomal Recessive Amelogenesis Imperfecta. Clin Genet. 95(3):375-383.PMID: 30506946.

Shin M, Chavez MB, Ikeda A, Foster BL, Bartlett JD. (2018) MMP20 Overexpression Disrupts Molar Ameloblast Polarity and Migration. J Dent Res, 97(7) 820-827

Suzuki M, Ikeda A, Bartlett JD. (2018) Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation. Arch Toxicol. 92(3):1283-1293

Courses Taught

DENT 7920: PhD seminar series
DENT 8008: Advanced Oral Histology and Embryology
DENT 6500: Histology, Cell Biology & Development
DENT 821: Orthodontic Materials
DENT 8840: Special Topics

Dental Emergency Care Clinic

7:30 a.m.-12 p.m.

7:30 a.m.-10:30 a.m.

Student Dental Clinics

8:00 a.m.-4:00 p.m.

Ohio State Dental Faculty Practice

7:30 a.m.-4:30 p.m.

Upper Arlington Dental Clinic

7:30 a.m.-5:30 p.m.

7:30 a.m.-4:30 p.m.

7:30 a.m.-12:30 p.m.