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Peter J. Reiser, MS, PhD

Academic Title

Chair, Division of Biosciences
Professor

Academic Division

Biosciences

Education

MS/Specialty
The Ohio State University, 1980, Physiology

PhD
The Ohio State University, 1981, Physiology

Contact

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Email: 
reiser.17@osu.edu
Phone: 
614-292-8476
Office Address: 
4165 Postle Hall
305 W. 12th Ave.
Columbus, OH 43210

Research Interests

We are exploring differences in muscle properties between species which are, in some cases, closely related phylogenetically and, in others, between species that are distantly related. The comparative approach is yielding new information on aspects of muscle physiology and contractile protein expression that are shared among a broad range of species, illustrating common, evolutionarily-conserved themes, while also highlighting striking differences between members of the same phylogenetic family, even differences between genera of the same family. We are also studying mammalian craniofacial muscles which have highly specialized motor functions, relative to functions of limb muscles that serve primarily locomotion. These functions include eye rotations around three independent axes by extraocular muscles, protection of the airway to prevent aspiration by intrinsic laryngeal muscles, and generation of bite forces by jaw-closing muscles. We are also combining out comparative interests by studying differences in craniofacial muscles between multiple mammalian species to determine how craniofacial muscle properties subserve species-specific motor functions. The research is focused on the roles of sarcomeric protein isoforms in regulating contractile properties of muscle. The approach is based primarily on analyses of contractile properties and protein composition of single, isolated muscle cells.

Publications

Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. Norden, D. M., Devine, R., Bicer, S., Jing, R., Reiser, P. J., Wold, L. E., Godbout, J. P. & McCarthy, D. O. Mar 1 2015 In : Physiology and Behavior. 140, p. 230-235 6 p.

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.  Norden, D. M., Bicer, S., Clark, Y., Jing, R., Henry, C. J., Wold, L. E., Reiser, P. J., Godbout, J. P. & McCarthy, D. O. Aug 15 2014 In : Brain, Behavior, and Immunity.

Electrophoretic separation of reptilian skeletal and cardiac muscle myosin heavy chain isoforms: Dependence on gel format.  Reiser, P. J. & Bicer, S. Jan 1 2014 In : Electrophoresis. 35, 18, p. 2615-2620 6 p.

Sex differences in myosin heavy chain isoforms of human failing and nonfailing atria.  Reiser, P. J. & Moravec, C. S. Jan 1 2014 In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 3

Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.  Bicer, S. & Reiser, P. J. Aug 1 2013 In : Journal of Muscle Research and Cell Motility. 34, 3-4, p. 211-231 21 p.

Insulin resistance does not inhibit the ability of overload to induce hypertrophy in the obese Zucker rat (Leprfa) plantaris.  Arnold, C. E., Doyle, J. A., Ingalls, C. P., Rupp, J. C., Reiser, P. J., Kakarla, S., Rice, K. M. & Blough, E. R. Jun 1 2013 In : Science and Sports. 28, 3, p. 133-139 7 p.

Very low force-generating ability and unusually high temperature dependency in hummingbird flight muscle fibers.  Reiser, P. J., Welch, K. C., Suarez, R. K. & Altshuler, D. L. Jun 1 2013 In : Journal of Experimental Biology. 216, 12, p. 2247-2256 10 p.

Regulation of contractile proteins and protein translational signaling in disused muscle.  Liu, H., Blough, E. R., Arvapalli, R., Wang, Y., Reiser, P. J., Paturi, S., Katta, A., Harris, R., Nepal, N. & Wu, M. Nov 1 2012 In : Cellular Physiology and Biochemistry. 30, 5, p. 1202-1214 13 p.

Patterns of tropomyosin and troponin-T isoform expression in jaw-closing muscles of mammals and reptiles that express masticatory myosin.  Bicer, S., Patel, R. J., Williams, J. B. & Reiser, P. J. Apr 1 2011 In : Journal of Experimental Biology. 214, 7, p. 1077-1085 9 p.

Three dimensional compartmentalization of myosin heavy chain isoforms in the human thyroarytenoid muscle.  Matrka, L. A., Reiser, P. J., Forrest, L. A. & Desilva, B. W. Oct 1 2010 In : Laryngoscope. 120, SUPPL. 3

Cardiac alterations in cancer-induced cachexia in mice.  Tian, M., Nishijima, Y., Asp, M. L., Stout, M. B., Reiser, P. J. & Belury, M. A. Aug 1 2010 In : International Journal of Oncology. 37, 2, p. 347-353 7 p.

The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1.  Reiser, P. J., Bicer, S., Patel, R., An, Y., Chen, Q. & Quan, N. May 15 2010 In : Journal of Experimental Biology. 213, 10, p. 1633-1642 10 p.

Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle.  Wright, V. P., Reiser, P. J. & Clanton, T. L. Dec 1 2009 In : Journal of Physiology. 587, 23, p. 5767-5781 15 p.

Masticatory ('superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles.  Reiser, P. J., Bicer, S., Chen, Q., Zhu, L. & Quan, N. Aug 15 2009 In : Journal of Experimental Biology. 212, 16, p. 2511-2519 9 p.

Induction of muscle weakness by local inflammation: An experimental animal model.  Bicer, S., Reiser, P. J., Ching, S. & Quan, N. Apr 1 2009 In : Inflammation Research. 58, 4, p. 175-183 9 p.

Myosin isoform expression in dog rectus muscles: Patterns in global and orbital layers and among single fibers.  Bicer, S. & Reiser, P. J. Jan 1 2009 In : Investigative Ophthalmology and Visual Science. 50, 1, p. 157-167 11 p.