Susan R. Mallery, DDS, MS, PhD, Receives $2.8M from National Cancer Institute
Dr. Susan R. Mallery is the Chair of the Division of Oral and Maxillofacial Pathology and Radiology at the College of Dentistry, and she is a practicing oral pathologist, teacher, and researcher. She recently was awarded a five-year, $2.8M clinical trial R01 grant from the National Institutes of Health National Cancer Institute.
The clinical trial, "Assessment of Chemopreventive Effects of a Mucoadhesive Patch on Premalignant Oral Epitheliel Lesions," will focus on determining the efficacy of fenretinide, a synthetic retinoid derivative that is related to vitamin A, as it is applied directly to precancerous oral lesions to prevent them from converting to cancer. Peter E. Larsen, DDS, Chair of the Division of Oral and Maxillofacial Surgery and Dental Anesthesiology, is a co-investigator for the clinical trial component of the grant.
As part of her research, Dr. Mallery has investigated a variety of agents to identify new methods and therapeutics to suppress and destroy cancerous cells. Her first breakthrough was the creation of an oral gel based on powerful antioxidants found in black raspberries that when applied to the mouth suppress genes associated with functions that allow cancerous cells to grow, thereby diminishing the risk of recurring lesions.
Along with her faculty appointment in the College of Dentistry, Dr. Mallery is a member of the Molecular Carcinogenesis and Chemoprevention Program at The Ohio State University's James Cancer Hospital, where her research focuses on AIDS-related oral cancer, oral pathology, oral cancer initiation and chemoprevention.