In alignment with the institutional goals, scientific research is the most prominent activity of the faculty in the Division of Biosciences. Within the past few years, the volume and scope of research in the section has increased greatly. All faculty have substantial external funding, and a major NIH-funded training grant for dental, graduate, and post-doctoral students and junior faculty. The myriad of ongoing multidisciplinary research programs focus on: Molecular and Cellular Biology, inflammation and Immunity, Developmental Biology, Chemical Senses, Musculoskeletal Biology, Microbiology, and Biomaterials and Tissue Engineering. The broad range of projects provided ample opportunities for scientific collaborations among faculty as well as offer opportunities for scientific collaborations among faculty as well as offer opportunities for graduate and post-doctoral students to obtain versatile training in modern approaches to biology.
The focus of my lab is in three areas that are related to Mechanobiology/bioengineering of cells of the musculoskeletal tissues: (i) mechanical stress-mediated intracellular signal transduction pathways that are involved in enhancing tissue's ability to self regenerate and repair cartilage and muscle; (ii) mechanisms of bone adaptation to mechanical forces; and (iii) synthesis of polymers for use as cell/gene delivery scaffolding matrix for cartilage and bone tissue engineering.
Dr. Bartlett's research has focused on understanding dental enamel development and the gene expression program that is required to form teeth. He has a particular interest in a gene called "matrix metalloproteinase-20" (MMP20), and he also is investigating the molecular events that cause dental fluorosis and the cellular interactions that are required for healthy enamel formation.
Currently, my research interests focus on the regulation of immunity and inflammation in mucosal surfaces. We also investigate means to utilize mucosal surfaces for provision of immunity against infectious diseases and strategies to control mucosal pathologies such as allergic reactions. For this purpose, we study adjuvants that could be used in mucosal vaccines to induce both mucosal and systemic immunity. Regulation of mucosal immunity by cytokines/chemokines and other innate factors represent the other major area of our research.
Microbial ecology of the oral environment, including: profiling the peri-implant microbiome in health, mucositis, and implantitis, host-microbial interaction, resistance and resilience of the microbiome to environmental perturbations. Whole metagenome and RNA-Seq analysis, fluorescent microscopy, scientific data visualization, visual analytics, software development, and reproducibility in science.
I study the molecular biology of tooth root development and mineralization, with interests including genes, mechanisms, diseases, and novel regeneration strategies.
Our research group studies the human oral microbiome and its relationship to health and disease. We currently have projects underway to study both dental caries and periodontitis. Our approach is interdisciplinary, using molecular biology, epidemiology, bioinformatics, community biology and ecology, and phylogenetics to study the relationship of bacterial communities to human health and disease.
Chemical, physical and biological properties of dental biomaterials; Optical properties of esthetic biomaterials and the theoretical bases for determining optical characteristics; Mathematical modeling of properties of biomaterials; Optimization of chemical compositions; Research design.
Dr. Kim's research interest entails Mechanobiology of Bone-Implant Interface, Tissue-Biomaterial Interactions, Bone Tissue Engineering, Mechanics of Total Joint Replacement, Micromechanics of Dental Implant Interface, Spine Mechanics, Computational Biomechanics, and Mechanics of Tooth Movement
My research focuses on studying oral bacterial profiles associated with periodontal health and disease using an integrated approach combining clinical research, epidemiology, molecular microbiology and bioinformatics. I am also interested in exploring the interaction between a health-compatible or a pathogenic bacterial colonization and the human host. I am also studying the role of host genetics on oral bacterial colonization. Current studies are directed towards understanding the role of the host genotype on determining host-specific bacterial colonization.
John J. Lannutti carries out research work in the area of electrospun scaffold for tissue engineering. Current interests lie in designing more biologically capable substrates that better mimic the diverse physical and biochemical environments needed to allow for the generation of fully capable neotissues. Professor Lannutti teaches a lecture class entitled “Materials in Medicine” and a laboratory entitled “Biomaterials Processing.”
Currently, my primary research interest is to investigate the possible mechanisms involved in delayed type mucosal wound healing. I collaborate with Oral Biology Division and Comprehensive Wound Center at OSU. We conduct both clinical and basic science research. I am also conducting several clinical research projects related to treatment outcome following implant placement surgery. We investigate early healing process at periodontal/peri-implant tissues. We combine clinical documentation with various molecular biology methods to evaluate different phases of healing.
We use an integrated approach that utilizes molecular biology, microbiology and epidemiology to study the molecular and population genetics of periodontitis-associated and other oral bacteria. We have developed a system for the detection and identification of bacterial strains (clonal types) of oral bacteria.By using PCR with species-specific primers, bacteria are detected directly from oral samples without the need for culturing. PCR products are sequenced to determine the genetic identity for individual clonal types and phylogenetic relationships among strains.
My research focus is hard-tissue biomaterials with an emphasis on new materials for orthopaedic and dental applications. This has including development and evaluation of a reduced-modulus acrylic bone cement and a hydroxyapatite-metal alloy composite for net-shaped manufacture of musculoskeletal implants. Continuing research projects in Orthopaedic BioMaterials Laboratory are investigating the use of shape-memory alloys for fracture fixation, micromotion between components of total hip arthroplasties, the determination of the specific origin of polyethylene wear debris in arthroplasty components, and the fatigue behavior of external fixators and dental prostheses.
Clinical Interests: Oral pathology, Research Interests: Oral cancer initiation; AIDS-related oral cancer; chemoprevention
My primary research interest is how the endocrine system affects the oral cavity and how tissues within the oral cavity may effect target tissues of endocrine hormones. The homeostasis of the periodontium is a complex, multifactorial relationship that involves, at least in part, the endocrine system. The assertion that hormone-sensitive periodontal tissues exist relies on several salient observations, including the retention and metabolic conversion of sex steroid hormones as well as the presence of steroid hormone receptors in periodontal tissues. These biological findings correlated with clinical observations confirm an increased prevalence of gingival diseases with fluctuating sex steroid hormone levels, even when oral hygiene remained unchanged. Both human and animal models are used to explore the relationship of sex steroid hormones to the oral cavity.
My research is focused on the roles of sarcomeric protein isoforms in regulating contractile properties of muscle. Specific areas of interest include craniofacial (extraocular, jaw-closing and laryngeal) muscles, limb skeletal muscles and cardiac muscle, with an emphasis on comparative muscle physiology and biochemistry. The approach is based primarily on analyses of contractile properties and protein composition of single, isolated muscle cells.
Dr. Satoskar’s research focuses on studying how cytokines regulate innate and acquired immune responses during infection and determining the strategies used by the parasite Leishmania to evade host immunity. The Laboratory uses murine model as well as variety of in vitro experimental approaches for these studies. Another area of interest in the laboratory is developing a vaccine against Leishmania by identifying and characterizing possible candidate antigens and optimizing effective vaccination strategies for them. Finally, a relatively new direction of the laboratory involves studying immune mechanisms that determine the outcome of a bioterror agent Francisella.
My research involves developing new polymeric materials for traditional dental materials and tissue engineering scaffolds. Projects involves synthesizing new materials, using cell culture to evaluate cell-material interactions and characterization of dental materials.
My research is focused on Dental Ceramics - Modeling and Laboratory Simulation of All-Ceramic Failure Mechanisms Optical and mechanical property evaluations of ceramic materials.
Dental Polymers/Ceramic Composites - Simulated wear characteristics of dental composites. New nanoparticulate reinforced polymers for dental applications. Polymerization shrinkage stress and strain of dental composite systems.
Dental Adhesion - Issues related to the bonding of materials to enamel and dentin.
Interactions among the nervous, endocrine and immune systems as they relate to viral pathogenesis, immunity, and tissue repair. Inflammatory and immune responses during viral infection and would healing. Effects of aging and stress on immunity; lymphocyte trafficking and activation; neuroendocrine regulation of cytokine and chemokine gene expression.
Dr. Sun's research interest is in the field of craniofacial growth and adaptation in response to mechanical loading. His research involves cranial sutures, mandibular osteodistraction sites, craniofacial periosteum and the dental alveolus.
Investigating molecular mechanism of pathophysiology in dental fluorosis focused on stress response (ER stress, oxidative stress ), adaptive response and epigenetic regulation.
Circuits in the brainstem reticular formation are necessary for coordinated oromotor function. Our lab is using neuroanatomical, neurophysiological and neuropharmacological approaches to analyze how these circuits process sensory information to switch between multiple behaviors.
Research in my lab investigates how the central nervous system processes sensory signals arising from the mouth. The oral cavity is richly innervated and supplies the organism with information critical to regulating eating and drinking. Our focus is the sense of taste, but we also study oral tactile and thermal sensations because all these modalities interact to give rise to the complex experience of flavor.
My interests include inflammation, signaling mechanisms involved in activation of polymorphonuclear leukocytes, PMN chemotactic peptide receptor polymorphisms and their association with aggressive periodontitis, and characterization of membrane transporters that move antimicrobial and anti-inflammatory agents used in periodontal therapy.
Research in my laboratory is focused on the molecular mechanisms of oral cancer development in humans and experimental tumor models, with an emphasis on elucidating the mechanisms by which a specific polymorphism within the TGFβ type I receptor increases cancer susceptibility and on the translational investigation of food-based approaches to cancer prevention.